Before embarking on a Kambo journey, it's crucial to consider certain contraindications that may render the treatment unsafe or unsuitable for certain individuals. Awareness of these contraindications is paramount to ensure the safety and well-being of participants. Let's explore these considerations to gain a comprehensive understanding of their implications. Certain medical conditions present significant risks when combined with Kambo treatment. These include aneurysms, active ulcers, alcohol dependency, Addison's disease, and any neurological conditions. Similarly, individuals with conditions such as blood clots, recent chemotherapy, or dependencies on substances like opioids and benzodiazepines should approach Kambo treatment with caution due to potential complications. Individuals with a history of gastric sleeve or band surgery, cardiac issues, or organ transplants should exercise caution when considering Kambo treatment. Likewise, individuals with a history of psychiatric disorders such as PTSD, bipolar disorder, schizophrenia, or personality disorders require specialized care from experienced practitioners. Full disclosure of any past psychiatric history and medicated low blood pressure is essential to ensure safe treatment. Additionally, recent surgeries, strokes, pregnancy, breastfeeding (under 6 months), or individuals under 18 years of age are advised against Kambo treatment due to potential risks.