Preparing for a journey with Kambo involves respecting the body's natural rhythms and optimizing receptivity to the medicine's transformative potential. Ahead of the treatment, observing an 8-hour fasting period is vital, abstaining from food intake. While staying hydrated is crucial, excessive water consumption should be avoided to prevent hyponatremia. Thus, it is advised to drink a modest amount of water, typically a small glass or two, on the day of the treatment to maintain hydration levels without overdoing it. During the Kambo session, which typically lasts between 20 to 45 minutes, participants are encouraged to embrace the healing process fully. To ready the body for the purgative effects of Kambo, consuming 1 to 1.5 liters of water 15 minutes prior to the application is recommended. This ensures sufficient hydration to aid in toxin expulsion and the release of pent-up emotions. The application of Kambo involves delicately placing the medicine under the skin's surface, facilitated by the gentle removal of the outermost layer of skin using a thin wooden stick. Through this method, Kambo is directly absorbed into the lymphatic system, bypassing the digestive tract, thus enabling swift and efficient assimilation.